Objective To research the effects of incorporating tetrapod-like zinc oxide whisker（T-ZnOw） of different proportions on the antibacterial activity of different kinds of soft denture liners. Methods The minimal inhibitory concentration（MIC） and minimal bactericidal concentration（MBC） of T-ZnOw against Saccharomyces albicans（S.albicans） were examined by the broth dilution test. Add T-ZnOw 0%, 1%, 2%, 3% to Silagum soft denture liners and soft denture liners respectively. The antimicrobial rate of S.albicans was determined by the membrane covering method. Results The MIC of T-ZnOw against S.albicans was 78 μg·mL-1 and the MBC was 156 μg·mL-1. Comparing 1%，2%，3% T-ZnOw group with control group, the results showed significant difference（P
