Objective To investigate the correlation between Helicobacter pylori（H.pylori） colonization in the oral
cavity and gastrointestinal disease. Methods 173 patients with gastrointestinal disease were grouped according to age, gender, periodontal status and types of gastrointestinal disease. H.pylori were detected from saliva samples of all patients by in vitro cultur. The H.pylori-positive rates in different groups were statistically analysed. Results The H.pylori-positive rate in all patients was 40.46% and the difference between male and female showed significant（P
