The aim of this study is to study genotype , transmission , clinical and pathological characteristics , and prognosis of oral condyloma acuminate (CA) in children. Methods : The authors retrospected the clinical characteristics and slices of HE staining of six cases which have been diagnosed as oral CA and , performed immunohistochemistry ( IHC) and in situ hybridization ( ISH) analysis to detect the DNA of human papilloma virus in 5 cases. Results : Oral CA often happened in the hard or soft plates of children of two-year-old. Most of them came from the families had been infected by human papilloma virus (HPV) . Histological examination demonstrated that koilocytes were common in the upper spinous and corneal layers. HPV was detected in all cases. HPV16P18- E6 antigen was positive in 4 of 5 cases examined. The result of ISH only show one case was HPV6- and HPV11- posi2 tive , and the other case was HPV-positive , but HPV could not be detected when recurring.Conclusion : The pathogen leading to oral condyloma acuminate (CA) and the transmission way of children may be different from that of adults.
