IL-1基因多态性与牙周炎关系的研究

The Association between IL-1 Gene Polymorphisms and Susceptibility to Severe Periodontitis

作者：段海燕　章锦才　张蕴惠

Author：Duan Haiyan,Zhang Jincai,Zhang Yunhui

收稿日期：2002-02-25 年卷（期）页码：2002,20(01):48-48-51. 摘要

期刊名称：华西口腔医学杂志

Journal Name：West China Journal of Stomatology

关键字：IL_1基因多态性,成人牙周炎,快速进展型牙周炎,

Key words：L-1 gene polymorphisms,adult periodontitis ,rapidly progressive periodontitis,

基金项目：

中文摘要

目的:研究中国汉族人IL-1 基因多态性与牙周炎易感性的关系。方法:收集30 例重度成人牙周炎(AP) 患者、20 例快速进展型牙周炎(RPP) 患者和94 例健康对照者的颊粘膜拭子,抽提DNA ,PCR-RELP 方法检测IL-1 基因簇基因多态性,比较三组患者各等位基因检出率的差异。结果:AP 组和RPP 组IL-1B + 3953PTaqI 等位基因Ⅱ的检出率均显著高于对照组(APP对照组OR = 618 ,RPPP对照组OR = 916 , P 0105) 。结论:中国汉族人中携带IL-1B + 3953PTaqI 等位基因Ⅱ和IL-1RN 内含子2PVNTR 等位基因Ⅱ可能是牙周炎的遗传易感因素;AP 和RPP 存在遗传异质性。

英文摘要

The purpose of this study was to investigate the relationship between IL-1 gene polymorphisms and susceptibility to severe periodontitis in Chinese of the Han Nationality.Methods : DNA samples with buccal swabs were collected from 30 pa2 tients with severe adult periodontitis (AP) , 20 patients with rapid progressive periodontitis (RPP) and 94 healthy control (HC) in2 dividuals. Polymorphisms in the IL-1 gene cluster were analyzed with PCR-RFLP. Results : It was found that the frequency of IL-1B + 3953PTaq I allele 2 was significantly higher in severe AP patients ( OR = 6. 8 , P

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论文摘要

IL-1基因多态性与牙周炎关系的研究

The Association between IL-1 Gene Polymorphisms and Susceptibility to Severe Periodontitis