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论文摘要

颌面部颗粒细胞瘤临床病理及免疫组织化学分析

Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor

作者:申泽良, 姚莉洪, 蒋鸿杰, 李茂, 汤亚玲

Author:Shen Zeliang, Yao Lihong, Jiang Hongjie, Li Mao, Tang Yaling.

收稿日期:2023-02-06          年卷(期)页码:2023,41(4):414-414-420

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:颗粒细胞瘤,临床病理,免疫组织化学,

Key words:granular cell tumor,clinicopathology,immunohistochemistry,

基金项目:四川大学华西口腔医院临床研究项目(LCYJ2019-8)

中文摘要

目的 借助免疫组织化学染色分析探讨颌面部颗粒细胞瘤(GCT)的临床组织病理特征。 方法 回顾性纳入7例颌面部GCT,分析颌面部GCT的镜下形态,免疫组织化学染色检测S-100、神经元特异性烯醇酶、SOX-10、CD68、肌动蛋白、结蛋白与Ki-67在GCT中的表达情况,并随访治疗效果。 结果 7例颌面部GCT肿瘤皆缺乏包膜,边界不清。镜下肿瘤细胞胞质内充满特征性嗜酸性颗粒。免疫组织化学结果显示,6例NSE阳性,5例S-100阳性,7例CD68阳性,5例SOX-10阳性,1例肌动蛋白阳性,7例结蛋白阴性,Ki-67阳性比例均不超过5%。随访的6例颌面部GCT均未复发。 结论 颌面部GCT具有特征性组织学结构,免疫组织化学S-100、CD68等指标可辅助诊断,临床切除后预后良好。

英文摘要

ObjectiveTo analyze the clinicopathological features of maxillofacial granular cell tumors (GCT) with the aid of immunohistochemical staining.MethodsSeven cases of maxillofacial GCT were retrospectively collated, and the microscopic morphology of maxillofacial GCT was analyzed. The expression of S-100, neuron-specific enolase (NSE), SOX-10, CD68, actin, desmin, and Ki-67 in GCT was detected by immunohistochemical staining. The cases were observed in the follow-ups after clinical treatment.ResultsAll seven GCT tumors lacked envelopes and were poorly defined. Microscopically, the sizes of the tumor cells were large and appeared with inconspicuous cell membranes, forming a syncytium-like appearance. The cytoplasm was filled with characteristic eosinophilic granules. The immunohistochemical results showed that six cases were NSE-positive, five cases were S-100-positive, seven cases were CD68-positive, five cases were SOX-10-positive, one case was actin-positive, and seven cases were desmin-negative. The Ki-67 index did not exceed 5% in all cases. In the follow-up sessions, none of the six cases presented a recurrence.ConclusionMaxillofacial GCT has a characteristic histological structure. Immunohistochemical S-100, CD68, and other indicators can assist in diagnosis, and the prognosis is good after clinical resection.

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