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论文摘要

海洛因诱导条件性位置偏爱大鼠顶叶联络皮质遥测脑电分析

Telemetry EEG of Parietal Association Cortex in Heroin-induced CPP Rats

作者:潘群皖, 朱再满, 李晶等

Author:PAN Qun-wan, ZHU Zai-man, LI Jing.et al

收稿日期:          年卷(期)页码:2014,45(1):84-88

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:海洛因 条件性位置偏爱 顶叶联络皮层 脑电无线遥测

Key words:Heroin Conditioned place preference Parietal association cortex Wireless telemetry

基金项目:

中文摘要

目的 记录海洛因诱导条件性位置偏爱 (CPP)大鼠顶叶联络皮质 (PtA)区脑电变化,分析其与觅药行为之间的关系。方法 大鼠PtA区脑立体定位电极埋藏,分成手术对照组和海洛因诱导组,后者制作海洛因依赖模型。利用CPP视频系统结合脑电无线遥测技术,记录各组大鼠在黑白箱停留、黑-白箱穿梭和白-黑箱穿梭时大鼠PtA区脑电变化,分析其各波百分比的差异。结果 与手术对照组比较,海洛因诱导组大鼠黑、白箱停留时,遥测脑电各波百分比差异无统计学意义,但海洛因诱导组大鼠穿梭时,与其停留状态脑电比较,右侧PtA脑电δ波百分比增加,β波、β2波百分比降低 (PPPPP

英文摘要

Objective?To determine the relationship between EEG changes of parietal association cortex (PtA) and drug-seeking behaviors of heroin-induced conditioned place preference (CPP) rats. Methods?Stereotaxic electrode was buried in the PtA of rats, which were then divided randomly into heroin-induced CPP group and operation-only control group. A CPP video system in combination with EEG wireless telemetry was used for recording PtA EEG and the behaviors of the rats-staying in black or white chamber of the video box; shuttling between black-white chambers or between white-black chambers. Results?No significant difference in percentage of the telemetry EEG waves was found between the two groups of rats when they stayed in the black or white chambers. The heroin-induced CPP rats had increased percentage of δ waves (PPP

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