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论文摘要

种植体周围炎小鼠模型的研究进展

Current Advances in Peri-implantitis Mouse Model

作者:朱睿, 刘蔚晴, 张鹏, 张紫涵, 梁星

Author:ZHU Rui, LIU Wei-qing, ZHANG Peng, ZHANG Zi-han, LIANG Xing

收稿日期:2020-07-15          年卷(期)页码:2020,51(6):767-770

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:种植体周围炎, 疾病模型, 小鼠模型, 建模方法

Key words:Peri-implantitis, Disease model, Mouse model, Modeling method

基金项目:

中文摘要

种植体周围炎是口腔种植修复最常见和棘手的并发症,是影响种植修复远期效果,导致种植失败的主要原因之一。由于研究手段的局限,其发病机制及病理过程尚未明确。动物模型是研究疾病发病机制的重要工具,随着种植技术的日臻成熟,种植体周围炎小鼠模型开始被用于基础实验研究。本文将结合国内外学者近年的研究进展,从小鼠模型的优势、小鼠品系的影响、微种植体的设计、微种植体植入的方式以及小鼠种植体周围炎的诱导方式五个方面进行综述,旨在为相关研究者提供参考和帮助。与种植体周围炎大动物模型相比,种植体周围炎小鼠模型使用更加灵活,较低的成本可以更好地控制样本量的大小,更短的建模时间可以更好地控制实验周期,小鼠基因组测序的完成,以及遗传操作系统的成熟使其发病机制的研究成为可能。但是,目前种植体周围炎小鼠模型仍存在一定的局限性,比如由于小鼠口腔大小的限制,种植手术操作的难度较大,复杂的干预措施难以实施,且由于种植体周围炎小鼠模型发展时间较短,种植体植入方法、种植体周围炎诱导方法等相关技术理论尚不统一,仍需要进一步地研究夯实理论。

英文摘要

Peri-implantitis is the most common and intractable complication of dental implant-supported prothesis affecting its long-term success, and is one of the main reasons for implant failure. Due to the limitation of the research methods, the pathogenesis and pathological processes of peri-implantitis remain unclear. Animal models are indispensable tools to study the pathogenesis of diseases. With the advances of the dental implants, the peri-implantitis mouse model has been used in experimental research. This paper summarized recent studies from the following five aspects: the advantages of the mouse model, the influence of mouse strain, the design of micro-implant, the way of implant insertion, as well as the induction of peri-implantitis, aiming to provide references and help for researchers. Compared with the large animal models of peri-implantitis, the mouse model of peri-implantitis is more flexible in use. Lower costs can better control the sample number and shorter induction time can better control experimental duration. The completion of mouse genome sequencing and the progress of the genetic operating system also make the pathogenetic study possible. However, the mouse model of peri-implantitis still has some limitations. Limited by the small size of mouse oral cavity, implant insertion surgery is technically demanding, and complex surgeries are even more challenging. Moreover, due to short history of the peri-implantitis mouse model, its corresponding technical theories such as implantation methods, peri-implantitis induction methods and so on are not unified yet and still need further research and development.

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