In order to study the effect of ARID1A on the migration of colon cancer cells, and to further analyze the mechanism of ARID1A regulating cell migration, the change of cell migration rate was observed by overexpression and interference of ARID1A gene in HCT116 cell line, and ARID1A co-expressed genes were screened out for GO and KEGG analysis by comparing the gene expression data between HCT116 and normal tissues. The results showed that overexpression of ARID1A reduced cell mobility, while the interference of this gene would lead to the opposite result. Among 1212 ARID1A co expressed genes with a correlation coefficient greater than 0.9, there are only 4 genes involved in cell proliferation and 29 genes involved in cell migration, which are associated with chemokine signaling pathway, cytokine receptor interaction and other signaling pathways. It is suggested that ARID1A can inhibit cell migration and regulate cell migration through multiple signaling pathways.
