Based on the directed relation graph with error propagation (DRGEP) reduction method and the computational singular perturbation(CSP) importance index method, a detailed mechanism of n-decane with 119 species and 373 reactions was simplified. A skeletal mechanism with 32 species and 73 reactions was thus obtained. By comparing the ignition delay time, the concentration profile of important species and extinction simulation results with the detailed mechanism, we find the skeletal mechanisms could reproduce the characteristics of the detailed mechanism and give the combustion characteristics of n-decane. The development of these models represents a significant step toward coupling of chemical reaction kinetics with computational fluid dynamics, and is a good basis for improving computational efficiency.