Periodontitis is a chronic infectious disease caused by dental plaque and the primary reason for tooth loss in adults because it damages periodontal supporting structures. Microbial plaque biofilm control is an effective method to prevent further disease progression. However, a reliable treatment that can lead to stable and satisfactory periodontal regeneration in clinical practice has not been reported to date. Exosome is a specific class of lipid-membrane-bound extracellular vesicle. Exosomes are secreted from cells through paracrine mechanism and participate in tissue regeneration. Considering that the application of exosomes provides a new strategy for tissue regeneration, this review presents the current status of exosomes derived from different kinds of cells for potential therapeutic use in periodontal regeneration.
