期刊导航

论文摘要

脂质体在医学中应用的新进展

New progress on application of liposomes in medicine

作者:蔡洁明综述 王茜审校

Author:CAI Jie-ming, WANG Qian

收稿日期:2009-02-02          年卷(期)页码:2009,36(6):698-700

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:脂质体,口腔医学,应用,

Key words:liposomes, stomatology, application,

基金项目:

中文摘要

脂质体是由磷脂双层构成的具有水相内核的脂质微囊。在其水相和脂质双分子层组成的膜内可以包裹多种物质,这使它成为一种新型的靶向给药制剂。该制剂具有靶向、长效、低毒、缓释、无免疫原性及保护包封药物等优点,已备受国内外广大医学研究者的关注,并且其研究发展的速度相当惊人。目前其应用已遍及生命科学及膜工程学等领域,并逐渐向临床应用发展。本文就脂质体在医学中应用的最新进展,尤其是它在口腔医学中的应用情况进行综述。

英文摘要

Liposomes are made of lipid bilayer and aqueous phase with the lipid core. A variety of drugs can be wrapped in its aqueous phase and lipid bilayer membrane. So it will be a new type of drugs which could encapsulate other drugs and release these drugs targeting and slowly increasing the local drugs concentration. The liposomes appear targeting property, long circulation, low toxicity, slow releasing, non-immunogenicity and protection potential. The advantage of the new type of drug has interested a lot of medical researchers. And it has become research hot topic at home and abroad, and the speed of research progress and development of liposomes is very quickly. At present, their application has been throughout the life science and membrane engineering, and gradually to the development of clinical applications. On clinical, they are more used as anti -cancer drugs in oral medicine and clinical medicine. In this paper, the latest developments on application of the liposomes in medicine, in particular the application of oral medicine was reviewed.

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