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论文摘要

β-葡萄糖醛酸苷酶与牙周炎的相关性研究进展

Research progress of relationship of β-glucuronidase and periodontitis

作者:黄满英综述 付云审校

Author:HUANG Man-ying, FU Yun

收稿日期:2009-02-04          年卷(期)页码:2009,36(4):426-428

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:牙周炎,β-葡萄糖醛酸苷酶,多形核白细胞,

Key words:periodontitis, β-glucuronidase, polymorphonuclear leukocyte,

基金项目:

中文摘要

内源性β-葡萄糖醛酸苷酶是溶酶体内的酸性水解酶,主要来源于多形核白细胞,是细胞外基质主要成分大分子蛋白聚糖降解的酶原之一,直接参与细胞外基质的降解过程。由于该酶与肿瘤的转移能力和炎症活动状态密切相关,故近年来其检测技术和研究意义备受关注。笔者下面主要就内源性β-葡萄糖醛酸苷酶的活性水平与牙周炎症之间的相关性及其相关性研究的实际意义作一综述。

英文摘要

Polymorphonuclear leukocytes(PMN) play a critical role in the process of periodontitis, including immunoprotection and immunity destruction. β -glucuronidase is a neutrophil -derived lysosomal acid hydrolase, which is an indicator of PMN influx into the gingival sulcus and is active in degradation of proteoglycans and the ground substance. This article will summary a review about β-glucuronidase and the relationship with periodontitis.

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