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论文摘要

甲基硫醇在牙周病病因学中作用的研究进展

The role of methyl mercaptan in the etiology of periodontitis

作者:马琴睿综述 何永红, 万呼春审校

Author:MA Qin-rui, HE Yong-hong, WAN Hu-chun

收稿日期:2008-08-20          年卷(期)页码:2009,36(3):361-363

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:甲基硫醇,L-甲硫氨酸-γ-水解酶,牙周可疑致病微生物,牙周病,

Key words:methyl mercaptan, L-methionine-γ-lyase, putative periodontal pathogen, periodontitis,

基金项目:

中文摘要

甲基硫醇是由特定的牙周可疑致病微生物在L-甲硫氨酸-γ-水解酶(METase)的催化下,代谢L-甲硫氨酸生成的。甲基硫醇可增加牙龈上皮的通透性,影响细胞骨架的重组;抑制牙龈、牙周结缔组织胶原以及细胞外基质的合成与分泌,从而影响细胞迁移;激活免疫级联反应,加速胶原的降解和牙槽骨的吸收。抑制METase活性即可抑制甲基硫醇的生成。本文就甲基硫醇的生成机制及其对牙周组织的破坏机制进行综述。

英文摘要

Methyl mercaptan is the metabolite of putative periodontal pathogen catalyzed by L-methionine-γ-lyase(METase). It plays an important role in cytoskeletal reorganization through increasing permeability of mucosa, cell migration through inhibiting synthesis and secretion of collagen and extracellular matrix, and in collagen degradation and alveolar bone resorption through immunological activities. Production of methyl mercaptan declines with inhibiting the enzyme activity. The objective of this article was to review the production of methyl mercaptan and the relationship of methyl mercaptan and periodontitis.

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