Adhesion,which is not a simple accumulation, but a more complex and organized process, is the foundation of colonization and pathogenicity of bacteria. Complex signal transduction happens among bacteria and acquired pellicle in these process. This paper from the mechanism of bacteria adhesion, types of bacteria signal transduction and the function of signal transduction in bacteria specific adhesion, approach the relationship between signal transduction and specific adhesion, provide a new way to think about inhibiting the formation of oral biofilm.