Endodontic interappointment pain is a common complication of root canal therapy. The main causative factors encompass mechanical, chemical, and microbial injury to the periradicular tissues during root canal therapy. In response to the injury, a large mass of chemical mediators are released or activated, and acute inflammation occurs at the periradicular tissues, which leads to the interappointment pain. Knowledge on the mechanisms of interappointment pain can help clinicians to take effective measures for prevention and management.
