The chemokines are a kind of small proteins with similar primary structures, which have various biological effect, mostly include chemotaxis of leukocyte, and play a significant regulating effect on the defense and the inflammatory reaction of the body. In recent years, a lot of researches have found that the chemokines play an important role in the immunopathogenesis of periodontitis. Therefore it is important to study the relation of chemokines and periodontitis for prevention, diagnosis, treatment and monitoring of curative effect of periodontitis.