Objective To detect the effect of dry socket treatment by metronidazole - dexamethasone - iodoform paste. Methods 60 cases with dry socket, divided into two groups of 30 cases each. One group was the test group, the other was the control group. Tooth extraction wounds were normally washed. Metronidazole- dexamethasone - iodoform paste was brushed on the wounds of test group. Iodoform was brushed on the wound of control group. Clinical effect of the two groups was compared. Results In test group, 28 cases gained obvious effect, and 2 gained normal effect. In control group, 10 cases gained obvious effect, and 20 gained normal effect. Test group obtained higher effect ratio(93.33%) compared with control group(33.33%). Statistical difference in the two group appears(P