E-cad和CD44v6在口腔鳞癌中的表达及意义

Significance and expression of E-cad and CD44v6 in oral and maxillofacial squamous cell carcinoma

作者：刘奕杉1，凌彬2，马旭东3，王善征3，林兆全2，刘耕3

Author：LIU Yi- shan1, LING Bin2, MA Xu- dong3, WANG Shan- zheng3, LIN Zhao- quan2, LIU Geng3.

收稿日期： 年卷（期）页码：2007,34(05):325-327

期刊名称：国际口腔医学杂志

Journal Name：International Journal of Stomatology

关键字：口腔颌面部鳞癌,黏附分子,免疫组织化学,

Key words：oral and maxillofacial squamous cell carcinoma, adhesion molecule, immunohistochemistry,

基金项目：

中文摘要

目的探讨黏附分子E-cad 和CD44v6 在口腔鳞癌中的表达及其与口腔颌面部鳞癌病理分级和侵袭转移的关系。方法采用免疫组织化学抗生蛋白链菌素- 生物素标记染色技术，对54例口腔颌面部鳞癌组织和15 例口腔颌面部正常组织进行E- cad 和CD44v6 表达的检测。结果口腔鳞癌组织E- cad 阳性表达率（50.00%）低于口腔正常组织的阳性表达率（86.67%），其差异有统计学意义（P

英文摘要

Objective To investigate the role of the adhesion molecule E- cad and CD44v6, and the relationship between the expression of E- cad and CD44v6 and the histopathological grade and lymph nodes metastasis in oral and maxillofacial squamous cell carcinoma（SCC）. Methods Immunohistochemical method（LSAB） was applied to examine the expression of E- cad and CD44v6 in 54 oral and maxillofacial SCC and 15 non- cancerous tissues. Results E - cad expression was positive in 50.00% of SCC versus in 86.67% of non - can cerous tissues. The positive rate of E- cad in SCC was lower than that in non- cancerous tissues（P

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论文摘要

E-cad和CD44v6在口腔鳞癌中的表达及意义

Significance and expression of E-cad and CD44v6 in oral and maxillofacial squamous cell carcinoma