Matrix extracellular phosphoglycoprotein（MEPE） is encoded by the gene m apping to the hum an chromosome 4q21.1. High expression is in the human oncogenic hypophosphatemic osteomalacia tumor. MEPE is considered to be a potential phosphatonins and inhibitor of mineralization. MEPE, referred to as minhibins, is identified in mature osteoblasts and osteocytes with a regulatory role in bone form ation and skeletal m ineralization. Moreover, based on refined gene mapping and expression by odontoblasts, MEPE is also thought to be a strong candidate gene for human dental structural diseases, including amelogenesis imperfecta, dentinogenesis imperfecta type Ⅱ，Ⅲ and dentin dysplasia type Ⅱ.
