Platelet -rich fibrin（PRF） is a new generation of platelet concentrate developed by Choukroun in 2000. Its processing is simple and without any additives, reducing the risk of infectious diseases’transmission. PRF fibrin network presents biochemical architecture of connected trimolecular or equilateral junctions. Thus, the flexible and elastic fibrin network is able to support cytokines enmeshment and cellular migration. It is rich in platelets and cytokines that can promote tissue healing and regeneration. It can also regulate inflammatory reactions. We present a review on PRF’s biological characteristics, regulation mechanism and clinical applications.
