Adipose-derived stem cells（ADSCs） are more abundant and easily accessible in harvest with less donor site lesion. Studies have observed the osteogenic differentiation potency of ADSCs induced by various means. Basing on the reports, the author reviews the biological characteristics and osteogenic induction methods of ADSCs, and the state of art of ADSCs bone tissue-engeering. Other potential influential factors such as gender, age and harvest location are also discussed. To date, ADSCs osteogenic differentiation has been identified in vivo and in vitro, however, further researches on amelioration of efficiency of ADSCs osteogenic differentiation and mechanism of those downstream adjusting genes involved in ADSCs bone tissue-engeering are still necessary.
