In human physiological environment, living organisms or cells always experience a wide variety of mechanical stimuli, such as patch membrane stretch, shear stress, osmotic challenge or high frequency vibration and so on. From this phenomenon, we have gradually focused on the mechnosensitivity of organisms. In previous articles, mechanosensitivity of ion channels has been proved to exist in mechanosensitive channel（MSC）, and nowadays more and more evidence has demonstrated that mechanosensitivity of voltage-gated channel（VGC） plays an important role in physiological and pathological process. In this review, on the basis of previous studies, we will elaborate on the mechanosensitivity and physiological functions of VGC.
