Carcinoma of the head and neck is one of the most common cancer, associated with major morbidity and mortality. Chemotherapy plays an important role in the combined and sequential management of head and neck cancer. Improvement in administration route has great clinical significance in the treatment of head and neck cancer. The routes are different, so are the clinical effects. Administration route of head and neck cancer chemotherapy can simply be divided as follows: Intravenous chemotherapy, intra-arterial chemotherapy, lymphatic chemotherapy, regional chemotherapy and combination of multiways chemotherapy. This paper reviewed the research advance and clinical application on the administration routes in the chemotherapy of head and neck cancer.
