In spite of the strength of dental ceramics far exceeds the occlusal stress, one severe concern for allceramic systems is their susceptibility to fatigue damage caused from long-term mastication. Mechanical simulation of a laboratory test is often used for pre-clinical investigations of dental materials and restorations, aiming at describing the fatigue behavior and predicting the catastrophic failures. This article presents a review of the experimental methods in research of dental restorations.