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论文摘要

口腔扁平苔藓中T 淋巴细胞亚群的研究进展

Research progress on T lymphocyte subsets of oral lichen planus

作者:刘雅菁综述 王文梅审校

Author:Liu Yajing, Wang Wenmei.

收稿日期:2010-12-18          年卷(期)页码:2011,38(4):433-435

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:口腔扁平苔藓, T 淋巴细胞亚群, 细胞免疫,

Key words:oral lichen planus, T lymphocyte subsets, cell-mediated immunity,

基金项目:

南京市医学科技发展重点基金资助项目(zkx10030)

中文摘要

口腔扁平苔藓(OLP)是一种发生于口腔黏膜的慢性自身免疫性疾病,可伴有皮肤、生殖道黏膜,指甲以 及毛发的病损。其组织病理学特征是上皮下淋巴细胞浸润带的形成、基膜的断裂和基底细胞液化变性。本文就 CD4+/CD8+ T 细胞与OLP,记忆T 细胞/原始T 细胞与OLP,Th1、Th2、Th9、Th17 细胞与OLP,调节性T 细胞与 OLP 等研究进展作一综述。

英文摘要

Oral lichen planus(OLP) is a chronic autoimmune disease of oral mucosal accompanied with lesions of skin, gential tract, nails and hair. The histology of OLP is characterized by a dense subepithelial band-like infiltrate of T lymphocytes, disruption of the epithelial basement membrane and degeneration of basal keratinocytes. This paper reviewed the research progresses of CD4+/CD8+ T cells and OLP, memory/naive T cells and OLP, Th1, Th2, Th9, Th17 cells and OLP, regulatory T cells and OLP, etc.

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