Enterococcus faecalis is a predominant organism that plays a major role in the etiology of persistent periradicular lesions after root canal treatment by forming biofilms. The matrix, which holds bacterial biofilms together, is a complex mixture of macromolecules including expolysaccharides, nucleic acid and protein. Extracelluar matrix contributes significantly to bacterial adhesion, biofilm structure and information exchanging between bacterias. This review mainly focused on the bioflim structure, extracelluar matrix and ways to eliminate the Enterococcus faecalis biofilm.
