Bone remodeling is of important value in dental research, and osteoclasts play a positive and nonsubstitutive role in bone remodeling. However, there are limited researches and clinical therapeutic strategy for bone diseases aiming at the coupling between osteoclasts and osteoblasts, in other words, making use of the positive effect of osteoclasts to promote bone remodeling. This review focused on research progress on the dynamic coupling between bone resorption and bone formation, the positive effect of osteoclasts to promote bone remodeling and its underlying molecular mechanism.
