For the characteristics of high recurrence and metastasis rate of oral cancer, a non-invasive and effective technology is required urgently for early diagnosis and screening of oral cancer and pre-cancerous lesion in clinic. Oral exfoliative cytological technique is a rapid, convenient and nonaggressive method which was used extensively to pre -cancerous lesion and the prophase of oral cancer screening, risk evaluation and moleculer marker detection. This article summarized the collection technology, analytical methods, existing problems and prospect of oral exfoliated cells for early diagnosis of oral canceration.
