In the physiological states, demineralization and remineralization of enamel is in the dynamic balance. When the environment changes, the balance can be broken. Demineralization not only led to morphological changes（ such as opaque spot）, but also the initial of caries. We should take effective measures to block this process, so that the direction of balance toword the remineralization. In the last decades, fluoride are widely used as an effective topical agent for the prevention of caries by promoting enamel remineralization. But the side -effects of fluoride can limiting its application. Recently, it has been founded that milk and cheese have the properties of anticariogenic, which attributed to the casein. Its tryptic digestion product of phosphopeptides（CPP） have the ability to bind amorphous calcium phosphate（ACP）. When the phosphopeptides appling to the surface of teeth, this can delive ring the calcium and phosphate ions, and enhances remineralization, prevents demineralization and reduces caries development. In this review, the structure and the source of CPP, the blend of CPP and ACP, the properties of enhances remineralization and prevents demineralization, the current evidence supporting of CPP-ACP, the interaction of CPP-ACP with fluoride, and the influence of the subsequent resin adhesion are in details.
