Objective To investigate the influence of Nimesulide（NIM）, a selective cyclo-oxygenase（COX）-2 inhibitor, on angiogenins（ang） gene expressions in human tongue squamous cell carcinoma Tca8113. Methods Tca8113 cells were treated with NIM（25, 50, 100, 200 μmol•L－1） for 48 h to meaure the expression of ang-2 mRNA in Tca8113 cells by the semiquantitative reverse transcription polymerase chain reaction analysis. Results The expression of ang-2 mRNA reduced in a concentration dependent manner. Conclusion NIM can down-regulate ang-2 gene expression, which may be involved in cancer angiogenesis inhibition mechanisms of COX-2 inhibitor.
