期刊导航

论文摘要

复方苯佐卡因凝胶对试验性牙痛模型的影响

Effects of Benzocaine compound gel on experimental toothache

作者:韦宝伟 刘布鸣 陈力力 刘元 姚树汉

Author:Wei Baowei, Liu Buming, Chen Lili, LiuYuan, Yao Shuhan.

收稿日期:2010-08-28          年卷(期)页码:2011,38(6):641-642

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:苯佐卡因,镇痛作用,家兔,大鼠,

Key words:Benzocaine,analgesic action,rabbit,rat,

基金项目:

中文摘要

目的 对比仿制药复方苯佐卡因凝胶与其被仿制品Orajel Mouth-Aid(OMA)的镇痛作用。方法 采用电刺激家兔牙髓法和光电刺激大鼠尾巴法。结果 局部给药后,复方苯佐卡因凝胶和OMA 均能提高动物痛阈,有良好的镇痛作用且具有剂量依赖性。结论 复方苯佐卡因凝胶和OMA 均有镇痛作用且作用强度相当,可用于牙痛的治疗。

英文摘要

Objective To compare analgesic efficacy of the copied Benzocaine compound gel and its original product Orajel Mouth-Aid, an over the counter drug product made in USA. Methods Pain thresholds in dental pulp of rabbits, and in tail flick of rat model were used. Results By topical application, these two products exhibited dose-dependent analgesic actions in rabbits and rats. Conclusion These two products have analgesic efficacy with similar potency, and they are good for toothache.

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