Objective To evaluate the clinical effects of pulse Nd:YAG laser combined with self-etching adhesive on restoration of molars with dental abrasion on occlusal surface. Methods 38 molars with dental abrasion on occlusal surface were restored from 15 patients. Each of the patients has at least two molars or premolars eligible. The experimental group were treated with pulse Nd:YAG laser combined with Adper Prompt L-Pop selfetching adhesive, while the control group were treated with Adper Prompt L-Pop directly. The cavity was restored with light-cured composite resin Z350. The modified United States Public Health Service criteria were used to evaluate the treatment effects at recall periods for one month, six months and twelve months. Results After 12 months, The successful rate of the experimental group(94.44%) was significantly higher than that of the control group(61.11%, P<0.05). The stimulation to the pulp of the experimental group was significantly higher than that of the control group statistically after one month(P <0.05). Statistically significant differences were observed between two groups for the retention and marginal adaptation of the restoration after 12 months(P<0.05). Conclusion Using of pulse Nd:YAG laser on molars with dental abrasion can improve the self-etch bonding strength of composite resin to tooth and decrease the post-operative sensitivity.