Objective To investigate the awareness of the oral hygiene knowledge and the satisfaction of people with removable partial denture(RPD) and the influence of RPD to oral soft and hard tissue, thus to provide suggestions for oral health education and RPD making. Methods 307 senior people in Chengdu wearing RPD were investigated, and the data were analyzed statistically. Results 307 people who were investigated have good oral hygiene habits and a higher percentage of using correct toothbrushing habits, but only 10.1% and 2.9% do scaling periodically and use dental floss respectively. The average longevity of RPD is 6.94 years. 93.8% of people think dentures should be changed unless they are broken. Only 1.0% of them pay subsequent visit every 3 to 6 months. More than 87.6% of them are satisfied with the RPD. 14.5% of abutment teeth are affected with caries. The cleanliness of the tissue surface is related to smoking, food impaction, removing dentures before going to bed or not, scaling, toothbrushing habits, denture longevity and cleaning methods of dentures in order. Conclusion RPD can achieve a preferable restoration effect. Those who wear RPD should strengthen the awareness of oral hygiene knowledge and pay subsequent visit periodically.