Color measurement instruments are able to quantify the surface color of everything. This method is objective and accurate. The two specialities of the instruments are the basis of the using in prosthodontics. Recent years, with the development of maxillofacial prosthetics, the simulation of restoration has become a goal to pursue in current prosthodontics. Patients are no longer limited to meet the application of functional restoration, but pay more attention to the aesthetic requirements. In this paper, we write a review about the color measurement instruments and their applications in stomatology.