Gap junction is a kind of membrane channel. It is widely spreaded in the bone which is updated and responds to the mechanical strain. Osteocytes transmit the mechanical signals to osteoblast and osteoclast which realize bone remolded, after it sensing the signals. Gap junction plays a very important role in the process of converting mechanical signals into biological effects. This article reviewed the discovery and the testing methods of gap junction, structures and functions of it, the function of mechanism of how the mechanical signals turn into biological effects.
