Periodontitis is a chronic infection caused by bacteria in dental plaque which is characterized by destruction of periodontal tissues caused by direct aggression of bacteria and host response. When periodontal tissues were stimulated by bacteria, a series of inflammatory signal pathways were activated and the expression of inflammatory mediators increased. Therefore, development of periodontitis may be regulated via the mediation of signaling pathways and inflammatory mediators. There were substantial researches concerning immunomodulatory treatment, and this article aimed to review new progress of immunomodulatory treatment applied in periodontitis.
