The properties of scaffolds are of great significance for bone tissue engineering. Silk protein harvested from natural materials such as silkworm or spider silk, has good biocompatibility, unique mechanical properties, and could serves as a drug sustained-release carrier. Silk protein material has been used as an ideal scaffold material for cell adhesion and growth in bone tissue engineering. This review summarizes investigations on the structure, biological characteristics of silk protein and its application in bone tissue engineering.
