Objective To evaluate effect of Chlorhexidine in preventing dry socket after impacted tooth extraction based on best evidence, and guide its clinical use. Methods Using Chlorhexidine and dry socket as keywords to search evidence-base medicine reviews from Cochrane library and American College of Physicians Journal Club to find the best relevant clinical evidence and evaluate quality of the evidence. Results According to the evidence, Chlorhexidine of mass fraction 0.12% can effectively reduce the incidence of dry socket, but research on the effect of various usage or drug formulations for Chlorhexidine is insufficient, further study is needed. Conclusion Chlorhexidine of mass fraction 0.12% can effectively reduce the incidence of dry socket in impacted tooth extraction.
