Human papillomavirus（HPV） infection is one of the important risky factors leading to cervical cancer. Recent studies show that the rate of its detection in oral tumor and precancerous lesions is also high, suggesting its relationship with the pathogenesis of oral tumor. Present research focuses mainly on its E6, E7 genes, less on other genes. In this paper, we discuss the HPV E5 gene, budding in papers of recent years, and make a brief review on the relationship between E5 gene and oral tumor.
