Cleft lip and palate is the most common congenital malformation in cranio-facial region, which will seriously affect the appearance and the growing development of the children. The cleft lip and palate reconstructive surgery is recommended to be performed before adolescence to obtain more satisfied outcome. However, young children, especially new born infants, have unique anatomical and functional characteristics. In order to get through the anesthesia period safely, anesthesiologists must be familiar with anatomy and physiology of anarcoticrelated features, selection suitable anesthesia methods and monitoring tools and maintain the physiological homeostasis as far as possible. This literature provides a brief summary of clinical application points for upper respiratory anatomy physiology and tracheal intubation, anesthesia preparation, implementation and management of anesthesia as well as anesthesia recovery in children with cleft lip and palate, so which will guide clinical practice.
