Streptococcus mutans（S.mutans）, which is considered as the chief pathogen of human caries, possesses the ability to form biofilm via sucrose-dependent adhesion, genesis and endure acids in the biofilm that may ultimately lead to dental caries. VicRK is one of the 13 putative two-component signal transduction systems of S.mutans that modulate the expression of cariogeneisis related virulence factors. This review summarized the mechanism, structural organization, physiological characteristics and the impact on the cariogenesis capabilities of VicRK， as well as the correlation between VicRK and VicX in S.mutans.
