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论文摘要

牙龈卟啉单胞菌与细胞自噬相关性的研究进展

Research progress on the association between Porphyromonas gingivalis and cell autophagy

作者:刘斌综述 梁景平审校

Author:Liu Bin, Liang Jingping.

收稿日期:2011-05-07          年卷(期)页码:2012,39(1):83-85

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:牙龈卟啉单胞菌, 细胞自噬, 感染, 血管内皮细胞,

Key words:Porphyromonas gingivalis, autophagy, infection, vascular endothelial cell,

基金项目:

上海市科委基础重点研究基金资助项目(09JC1409100)

中文摘要

细胞自噬是真核细胞的溶酶体依赖的代谢机制之一,参与宿主抵御病原菌感染的过程。牙龈卟啉单胞菌(P.gingivalis)能够侵入血管内皮细胞并利用自噬逃避宿主清除、持续并传播感染。本文就P.gingivalis与细胞自噬相关性研究的进展作一综述。

英文摘要

Autophagy is a lysosome dependent metabolic mechanism of eukaryotic cells, which is involved in the host defense progress against pathogen infection. Porphyromonas gingivalis(P. gingivalis) could invade the vascular endothelial cells and take advantage of autophagy to escape the clearance of the host, leading to the persistence and transmission of infection. The purpose of the article is to discuss the progress on the association between P. gingivalis and cell autophagy.

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