Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China） [Abstract] Tissue-engineered oral mucosal equivalents have been developed for clinical applications, such as restore the soft tissue defects due to excision of tumor, parodontopathy, trauma and so on. In the last several decades, researches have mainly concentrated on the development of epithelial cell culture methods and introducing new dermal scaffolds. In this review we will focus on the oral mucosa equivalent reconstructed models, the scaffold, the important role of the extracellular matrix, and display the new concept of tissue engineering and the new application of oral mucosa tissue engineering.
