Growth factors, which are fundamental regulators of tissue repair, play an essential role in periodontal tissue regeneration. But we can’t receive desired results when applying them directly for their short elimination half-life in vivo. For this reason, many domestic and international scholars are exploring the ways to make growth factors releasing sustainable and effective. Preparing growth factor controlled-release microspheres and using intelligent controlled-release carrier materials can make growth factors released slowly and sustainable; genetic engineering, which integrates target gene of growth factors into target cells by carriers, also can make growth factors expressing sustainable and limited in cells and tissues. Both methods are expected to solve the problem that growth factors can’t play their biological role effectively. This paper will make a review on setting up sustained and controlled release system and gene therapy.
