Local anesthetic administration is a common dental procedure in clinical practice. The incidence rate of complications and side effects is about 4.5% to 13%, and almost of them are usually of a reversible and temporary nature, though the potential for a more serious response does exist. The complications of local anesthesia include systemic and local adverse reaction, which is involved in much type of signs and symptoms. The prevention and treatment should be carefully considered when it occurs. Thus, dental doctors should not only master the theory and techniques of local anesthesia before anesthetic injection, but also are familiar with prevention and treatment of complications. This paper focus on the frequent complications in anesthesia practice, and the principles related to prevention and cure of complications were discussed.