Orthodontic pain is the most common symptom, which affects not only the clinical effect of orthodontic treatment, but also patients’intention to receive orthodontic treatment. Reports revealed that 95% of orthodontic patients had suffered varying degrees of pain. How to eliminate or release orthodontic pain, to ensure the effectiveness of orthodontic treatment, and to improve the oral health care quality effectively have become the concerns among orthodontists and patients. In this review, we summarized the clinical feature and possible mechanisms of orthodontic pain, meanwhile compared the different pain relief schemes commonly used in clinical case, and analyzed the peripheral mechanism involved in orthodontic pain for practical protocol of clinical analgesia.
