Platelet-rich fibrin（PRF） is a source of autogenic neotype biomaterial, which is rich in cytokine and growth factors, and is called new generation of platelet concentrates. The molecular constitution of PRF is similar to nature blood clot, and to provide location with migration, proliferation, and differentiation for rhagiocrine cell. Recently, many researchers use PRF as graft on the sinus floor elevation in dental implantation and win well results. This article reviewed PRF and its application on sinus floor elevation in dental implantation.
