As a caries-preventive agent, fluoride could probably lead to fluoride-resistant strains of Streptococcus mutans（S.mutans） with its wide application in the daily life. In order to understand the cariogenic changes in virulence of the fluoride-resistant strains of S.mutans, scholars conducted various studies concerning their ultrastructure, adhesion, acid resistance, acid production and demineralization ability, as well as cariogenic related genes and other molecular biological characteristics. This article was committed to review the research progress in recent years.
