As an important neurotransmitter, adenosine triphosphate（ATP） has a wide range of biological effects. A variety of noxious stimulation can cause trigeminal ganglion neurons releasing ATP, and ATP can induce pain through activation of P2 receptors. P2 receptors can be divided into P2X and P2Y receptors. And P2Y receptors expression significantly increased in impaired trigeminal ganglion neurons. In here, the research progress of the relevance of ATP and the expression of P2Y receptor, the signal transduction mechanisms of P2Y receptor which in TG, and the transduction of P2Y receptor on nerve injury pain signal were reviewed.
