As one of the most important regulatory systems, Wnt signaling pathway is stimulated very quickly by biomechanical stimulation in osteocytes, which function as key mechanosensory cells in bone. The stimulating procedure is influenced by lots of factors and finally results in regulation of gene expression and bone remolding. This review concludes the research advances concerning the relationship between Wnt signaling pathway and mechanotransduction in osteocytes, and major regulatory factors on the pathway’s stimulation.
